Yap1
Yap1
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YAP1
YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcriptional regulator by activating the transcription of

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YAP1Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes

1JMQ, 1K5R, 1K9Q, 1K9R, 2LAW, 2LAX, 2LAY, 2LTV, 2LTW, 3KYS, 3MHR, 4RE1, 4REX

IdentifiersAliasesYAP1, COB1, YAP, YAP2, YAP65, YKI, Yes associated protein 1, YapExternal IDsOMIM: 606608 MGI: 103262 HomoloGene: 4452 GeneCards: YAP1 Gene location (Human)Chr.Chromosome 11 (human)[1]Band11q22.1Start102,110,447 bp[1]End102,233,424 bp[1]Gene location (Mouse)Chr.Chromosome 9 (mouse)[2]Band9|9 A1Start7,931,999 bp[2]End8,004,596 bp[2]Gene ontologyMolecular function• transcription corepressor activity
• protein binding
• transcription regulatory region DNA binding
• activating transcription factor binding
• protein heterodimerization activity
• RNA polymerase II core promoter proximal region sequence-specific DNA binding
• transcription factor activity, RNA polymerase II transcription factor binding
• chromatin binding
• transcription coactivator activity
• protein C-terminus binding
• proline-rich region binding
• transcription factor binding
Cellular component• cytoplasm
• nucleoplasm
• cell nucleus
• TEAD-1-YAP complex
• TEAD-2-YAP complex
• transcription factor complex
• cytosol
• membrane
Biological process• regulation of transcription, DNA-templated
• contact inhibition
• transcription, DNA-templated
• cellular response to DNA damage stimulus
• cellular response to gamma radiation
• transcription initiation from RNA polymerase II promoter
• cell proliferation
• regulation of neurogenesis
• negative regulation of nucleic acid-templated transcription
• positive regulation of transcription, DNA-templated
• regulation of hematopoietic stem cell differentiation
• response to progesterone
• positive regulation of intracellular estrogen receptor signaling pathway
• progesterone receptor signaling pathway
• cell morphogenesis
• vasculogenesis
• embryonic heart tube morphogenesis
• positive regulation of cell proliferation
• regulation of keratinocyte proliferation
• keratinocyte differentiation
• negative regulation of epithelial cell differentiation
• notochord development
• somatic stem cell population maintenance
• hippo signaling
• regulation of cell proliferation
• positive regulation of transcription from RNA polymerase II promoter
• positive regulation of organ growth
• paraxial mesoderm development
• lateral mesoderm development
• bud elongation involved in lung branching
• lung epithelial cell differentiation
• regulation of canonical Wnt signaling pathway
• cellular response to retinoic acid
• regulation of stem cell proliferation
• regulation of metanephric nephron tubule epithelial cell differentiation
• positive regulation of canonical Wnt signaling pathway
• positive regulation of stem cell population maintenance
• negative regulation of stem cell differentiation
• negative regulation of extrinsic apoptotic signaling pathway
• macromolecular complex assembly
• tissue homeostasis
• heart process
• positive regulation of cardiac muscle cell proliferation
• cardiac muscle tissue regeneration
• regulation of gene expression
Sources:Amigo / QuickGOOrthologsSpeciesHumanMouseEntrezEnsemblUniProtRefSeq (mRNA)NM_001130145
NM_001195044
NM_001195045
NM_001282097
NM_001282098

NM_001282099
NM_001282100
NM_001282101
NM_006106

NM_001171147
NM_009534

RefSeq (protein)NP_001123617
NP_001181973
NP_001181974
NP_001269026
NP_001269027

NP_001269028
NP_001269029
NP_001269030
NP_006097

NP_001164618
NP_033560

Location (UCSC)Chr 11: 102.11 – 102.23 MbChr 9: 7.93 – 8 MbPubMed search[3][4]WikidataView/Edit HumanView/Edit Mouse

YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcriptional regulator by activating the transcription of genes involved in cell proliferation and suppressing apoptotic genes. YAP1 is inhibited in the Hippo signaling pathway which allows the cellular control of organ size and tumor suppression. YAP1 was first identified by virtue of its ability to associate with the SH3 domain of Yes and Src protein tyrosine kinases.[5] YAP1 is a potent oncogene, which is amplified in various human cancers.[6][7]

Contents
  • 1 Structure
  • 2 Function
  • 3 Clinical significance
  • 4 References
Structure Modular Structure of YAP1 Isoforms

Cloning of the YAP1 gene facilitated the identification of a modular protein domain, known as the WW domain.[8][9][10] Two splice isoforms of the YAP1 gene product were initially identified, named YAP1-1 and YAP1-2, which differed by the presence of an extra 38 amino acids that encoded the WW domain.[11][12] Apart from the WW domain, the modular structure of YAP1 contains a proline-rich region at the very amino terminus, which is followed by a TID (TEAD transcription factor interacting domain).[13] Next, following a single WW domain, which is present in the YAP1-1 isoform, and two WW domains, which are present in the YAP1-2 isoform, there is the SH3-BM (Src Homology 3 binding motif).[5][14] Following the SH3-BM is a TAD (transcription activation domain) and a PDZ domain-binding motif (PDZ-BM) (Figure 1).[15][16]

Function

YAP1 is a transcriptional co-activator[17] and its proliferative and oncogenic activity is driven by its association with the TEAD family of transcription factors,[13] which up-regulate genes that promote cell growth and inhibit apoptosis.[18] Several other functional partners of YAP1 were identified, including RUNX,[17] SMADs,[19][20] p73,[21] ErbB4,[22][23] TP53BP,[24] LATS1/2,[25] PTPN14,[26] AMOTs,[27][28][29][30] and ZO1/2.[31] YAP1 and its close paralog, TAZ (WWTR1), are the main effectors of the Hippo tumor suppressor pathway.[32] When the pathway is activated, YAP1 and TAZ are phosphorylated on a serine residue and sequestered in the cytoplasm by 14-3-3 proteins.[32] When the Hippo pathway is not activated, YAP1/TAZ enter the nucleus and regulate gene expression.[32]

It is reported that several genes are regulated by YAP1, including Birc2, Birc5, connective tissue growth factor (CTGF), amphiregulin (AREG), Cyr61, Hoxa1 and Hoxc13.

YAP/TAZ have also been shown to act as stiffness sensors, regulating mechanotransduction independently of the Hippo signalling cascade.[33]

Clinical significance

Heterozygous loss-of-function mutations in the YAP1 gene have been identified in two families with major eye malformations with or without extra-ocular features such as hearing loss, cleft lip, intellectual disability and renal disease.[34]

The YAP1 oncogene serves as a target for the development of new cancer drugs.[35] Small compounds have been identified that disrupt the YAP1-TEAD complex or block the binding function of WW domains.[36][37] These small molecules represent lead compounds for the development of therapies for cancer patients, who harbor amplified or overexpressed YAP oncogene.

The Hippo/YAP signaling pathway may exert neuroprotective effects through mitigating blood-brain barrier disruption after cerebral ischemia/reperfusion injury.[38]

References
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137693 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053110 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Sudol M (August 1994). "Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product". Oncogene. 9 (8): 2145–52. PMID 8035999.
  6. ^ Huang J, Wu S, Barrera J, Matthews K, Pan D (August 2005). "The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP". Cell. 122 (3): 421–34. doi:10.1016/j.cell.2005.06.007. PMID 16096061.
  7. ^ Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA (August 2006). "Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon". Proceedings of the National Academy of Sciences of the United States of America. 103 (33): 12405–10. Bibcode:2006PNAS..10312405O. doi:10.1073/pnas.0605579103. PMC 1533802. PMID 16894141.
  8. ^ Bork P, Sudol M (December 1994). "The WW domain: a signalling site in dystrophin?". Trends in Biochemical Sciences. 19 (12): 531–3. doi:10.1016/0968-0004(94)90053-1. PMID 7846762.
  9. ^ André B, Springael JY (December 1994). "WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65". Biochemical and Biophysical Research Communications. 205 (2): 1201–5. doi:10.1006/bbrc.1994.2793. PMID 7802651.
  10. ^ Hofmann K, Bucher P (January 1995). "The rsp5-domain is shared by proteins of diverse functions". FEBS Letters. 358 (2): 153–7. doi:10.1016/0014-5793(94)01415-W. PMID 7828727.
  11. ^ Sudol M, Bork P, Einbond A, Kastury K, Druck T, Negrini M, Huebner K, Lehman D (June 1995). "Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain". The Journal of Biological Chemistry. 270 (24): 14733–41. doi:10.1074/jbc.270.24.14733. PMID 7782338.
  12. ^ Gaffney CJ, Oka T, Mazack V, Hilman D, Gat U, Muramatsu T, Inazawa J, Golden A, Carey DJ, Farooq A, Tromp G, Sudol M (November 2012). "Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene". Gene. 509 (2): 215–22. doi:10.1016/j.gene.2012.08.025. PMC 3455135. PMID 22939869.
  13. ^ a b Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML (May 2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes & Development. 15 (10): 1229–41. doi:10.1101/gad.888601. PMC 313800. PMID 11358867.
  14. ^ Ren R, Mayer BJ, Cicchetti P, Baltimore D (February 1993). "Identification of a ten-amino acid proline-rich SH3 binding site". Science. 259 (5098): 1157–61. Bibcode:1993Sci...259.1157R. doi:10.1126/science.8438166. PMID 8438166.
  15. ^ Wang S, Raab RW, Schatz PJ, Guggino WB, Li M (May 1998). "Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)". FEBS Letters. 427 (1): 103–8. doi:10.1016/S0014-5793(98)00402-5. PMID 9613608.
  16. ^ Mohler PJ, Kreda SM, Boucher RC, Sudol M, Stutts MJ, Milgram SL (November 1999). "Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50". The Journal of Cell Biology. 147 (4): 879–90. doi:10.1083/jcb.147.4.879. PMC 2156157. PMID 10562288.
  17. ^ a b Yagi R, Chen LF, Shigesada K, Murakami Y, Ito Y (May 1999). "A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator". The EMBO Journal. 18 (9): 2551–62. doi:10.1093/emboj/18.9.2551. PMC 1171336. PMID 10228168.
  18. ^ Zhao B, Kim J, Ye X, Lai ZC, Guan KL (February 2009). "Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein". Cancer Research. 69 (3): 1089–98. doi:10.1158/0008-5472.CAN-08-2997. PMID 19141641.
  19. ^ Ferrigno O, Lallemand F, Verrecchia F, L'Hoste S, Camonis J, Atfi A, Mauviel A (July 2002). "Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling". Oncogene. 21 (32): 4879–84. doi:10.1038/sj.onc.1205623. PMID 12118366.
  20. ^ Aragón E, Goerner N, Xi Q, Gomes T, Gao S, Massagué J, Macias MJ (October 2012). "Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways". Structure. 20 (10): 1726–36. doi:10.1016/j.str.2012.07.014. PMC 3472128. PMID 22921829.
  21. ^ Strano S, Munarriz E, Rossi M, Castagnoli L, Shaul Y, Sacchi A, Oren M, Sudol M, Cesareni G, Blandino G (May 2001). "Physical interaction with Yes-associated protein enhances p73 transcriptional activity". The Journal of Biological Chemistry. 276 (18): 15164–73. doi:10.1074/jbc.M010484200. PMID 11278685.
  22. ^ Komuro A, Nagai M, Navin NE, Sudol M (August 2003). "WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus". The Journal of Biological Chemistry. 278 (35): 33334–41. doi:10.1074/jbc.M305597200. PMID 12807903.
  23. ^ Omerovic J, Puggioni EM, Napoletano S, Visco V, Fraioli R, Frati L, Gulino A, Alimandi M (April 2004). "Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level". Experimental Cell Research. 294 (2): 469–79. doi:10.1016/j.yexcr.2003.12.002. PMID 15023535.
  24. ^ Espanel X, Sudol M (April 2001). "Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains". The Journal of Biological Chemistry. 276 (17): 14514–23. doi:10.1074/jbc.M008568200. PMID 11278422.
  25. ^ Oka T, Mazack V, Sudol M (October 2008). "Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)". The Journal of Biological Chemistry. 283 (41): 27534–46. doi:10.1074/jbc.M804380200. PMID 18640976.
  26. ^ Liu X, Yang N, Figel SA, Wilson KE, Morrison CD, Gelman IH, Zhang J (March 2013). "PTPN14 interacts with and negatively regulates the oncogenic function of YAP". Oncogene. 32 (10): 1266–73. doi:10.1038/onc.2012.147. PMC 4402938. PMID 22525271.
  27. ^ Wang W, Huang J, Chen J (February 2011). "Angiomotin-like proteins associate with and negatively regulate YAP1". The Journal of Biological Chemistry. 286 (6): 4364–70. doi:10.1074/jbc.C110.205401. PMC 3039387. PMID 21187284.
  28. ^ Chan SW, Lim CJ, Chong YF, Pobbati AV, Huang C, Hong W (March 2011). "Hippo pathway-independent restriction of TAZ and YAP by angiomotin". The Journal of Biological Chemistry. 286 (9): 7018–26. doi:10.1074/jbc.C110.212621. PMC 3044958. PMID 21224387.
  29. ^ Zhao B, Li L, Lu Q, Wang LH, Liu CY, Lei Q, Guan KL (January 2011). "Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein". Genes & Development. 25 (1): 51–63. doi:10.1101/gad.2000111. PMC 3012936. PMID 21205866.
  30. ^ Oka T, Schmitt AP, Sudol M (January 2012). "Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP". Oncogene. 31 (1): 128–34. doi:10.1038/onc.2011.216. PMID 21685940.
  31. ^ Oka T, Remue E, Meerschaert K, Vanloo B, Boucherie C, Gfeller D, Bader GD, Sidhu SS, Vandekerckhove J, Gettemans J, Sudol M (December 2010). "Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling". The Biochemical Journal (Submitted manuscript). 432 (3): 461–72. doi:10.1042/BJ20100870. hdl:1854/LU-1256657. PMID 20868367.
  32. ^ a b c Pan D (October 2010). "The hippo signaling pathway in development and cancer". Developmental Cell. 19 (4): 491–505. doi:10.1016/j.devcel.2010.09.011. PMC 3124840. PMID 20951342.
  33. ^ McMurray RJ, Dalby MJ, Tsimbouri PM (May 2015). "Using biomaterials to study stem cell mechanotransduction, growth and differentiation". Journal of Tissue Engineering and Regenerative Medicine. 9 (5): 528–39. doi:10.1002/term.1957. PMID 25370612.
  34. ^ Williamson KA, Rainger J, Floyd JA, Ansari M, Meynert A, Aldridge KV, Rainger JK, Anderson CA, Moore AT, Hurles ME, Clarke A, van Heyningen V, Verloes A, Taylor MS, Wilkie AO, Fitzpatrick DR (February 2014). "Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects". American Journal of Human Genetics. 94 (2): 295–302. doi:10.1016/j.ajhg.2014.01.001. PMC 3928658. PMID 24462371.
  35. ^ Sudol M, Shields DC, Farooq A (September 2012). "Structures of YAP protein domains reveal promising targets for development of new cancer drugs". Seminars in Cell & Developmental Biology. 23 (7): 827–33. doi:10.1016/j.semcdb.2012.05.002. PMC 3427467. PMID 22609812.
  36. ^ Liu-Chittenden Y, Huang B, Shim JS, Chen Q, Lee SJ, Anders RA, Liu JO, Pan D (June 2012). "Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP". Genes & Development. 26 (12): 1300–5. doi:10.1101/gad.192856.112. PMC 3387657. PMID 22677547.
  37. ^ Kang SG, Huynh T, Zhou R (2012). "Non-destructive inhibition of metallofullerenol Gd@C(82)(OH)(22) on WW domain: implication on signal transduction pathway". Scientific Reports. 2: 957. Bibcode:2012NatSR...2E.957K. doi:10.1038/srep00957. PMC 3518810. PMID 23233876.
  38. ^ Gong P, Zhang Z, Zou C, et al. (August 2018). "Hippo/YAP signaling pathway mitigates blood-brain barrier disruption after cerebral ischemia/reperfusion injury". Behavioural Brain Research. 356: 8–17. doi:10.1016/j.bbr.2018.08.003. PMC 6193462. PMID 30092249.
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Signaling pathway: Hippo signaling pathwayReceptor
  • FAT4
Adaptor protein
  • NF2
  • FRMD6
  • SAV1
  • MOBKL1A
  • MOBKL1B
Kinase
  • MST1
  • LATS1
  • LATS2
  • STK3
Transcription factor
  • YAP1
  • TAZ
Other/unknown
  • RASSF1


Yu-Gi-Oh! - Jinzo (YAP1-EN007) - Anniversary Pack - Limited Edition - Ultra Rare
Yu-Gi-Oh! - Jinzo (YAP1-EN007) - Anniversary Pack - Limited Edition - Ultra Rare
Yu-Gi-Oh! is a strategic trading card game in two players Duel each other using a variety of Monster, Spell, and Trap Cards to defeat their opponent's monsters and be the first to drop the other's Life Points to 0.Card Name: JinzoCard Type: Effect MonsterCard Number: YAP1-EN007Set: Anniversary PackAttack/Defense: 2400/1500Attribute: DarkLevel: 6 Monster Type: MachinePasscode: 77585513Card Text: As long as this card remains face-up on the field, Trap Cards cannot be activated. The effects of all face-up Trap Cards are negated.

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Yu-Gi-Oh! - Shiba-Warrior Taro (YAP1-EN008) - Anniversary Pack - Limited Edition - Ultra Rare
Yu-Gi-Oh! - Shiba-Warrior Taro (YAP1-EN008) - Anniversary Pack - Limited Edition - Ultra Rare
Yu-Gi-Oh! is a strategic trading card game in two players Duel each other using a variety of Monster, Spell, and Trap Cards to defeat their opponent's monsters and be the first to drop the other's Life Points to 0.Card Name: Shiba-Warrior TaroCard Type: Effect MonsterCard Number: YAP1-EN008Set: Anniversary PackAttack/Defense: 800/600Attribute: EarthLevel: 2 Monster Type: Beast-WarriorPasscode: 27416701Card Text: This card cannot be destroyed by battle. When a card on the field is destroyed by battle or by a card effect, return this face-up card to its owner's hand.

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Yu-Gi-Oh! - Red-Eyes B. Dragon (YAP1-EN002) - Anniversary Pack - Limited Edition - Ultra Rare
Yu-Gi-Oh! - Red-Eyes B. Dragon (YAP1-EN002) - Anniversary Pack - Limited Edition - Ultra Rare
Yu-Gi-Oh! is a strategic trading card game in two players Duel each other using a variety of Monster, Spell, and Trap Cards to defeat their opponent's monsters and be the first to drop the other's Life Points to 0.Card Name: Red-Eyes B. DragonCard Type: Normal MonsterCard Number: YAP1-EN002Set: Anniversary PackAttack/Defense: 2400/2000Attribute: DarkLevel: 7 Monster Type: DragonPasscode: 74677422Card Text: A ferocious dragon with a deadly attack.

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YAP1 Blocking Peptide
YAP1 Blocking Peptide
YAP1 Blocking Peptide is a blocking peptide. http://www.abbexa.com/yap1-blocking-peptide

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Konami Yu-Gi-Oh! YAP1-JP006 Dark Magician Girl Ultra Rare
Konami Yu-Gi-Oh! YAP1-JP006 Dark Magician Girl Ultra Rare
Yu-Gi-Oh! Single Card YAP1-JP006 Dark Magician Girl Ultra Rare

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Yu-Gi-Oh! / 6th Period / YAP1-JP001 Blue Eye White Dragon 【Ultra Lea】
Yu-Gi-Oh! / 6th Period / YAP1-JP001 Blue Eye White Dragon 【Ultra Lea】
Yu-Gi-Oh / 6th Period / YAP1-JP001 Blue Eye White Dragon 【Ultra Lea】

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The Hippo Signaling Pathway and Cancer
The Hippo Signaling Pathway and Cancer
​​The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorigenesis, and many leading scientists are showing increased interest in this growing field and it's relation to cancer.  The chapters in this volume cover virtually all aspects of tumor biology, because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Ras, Wnt, TGFbeta and p53. Moreover, Hippo signaling is not solely involved in regulating “classic” tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. The primary audience are researchers interested in basic science in the areas of tumor suppression, cell cycle and size regulation, development and differentiation. 

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Rabbit Anti-YAP1(Tyr407) Polyclonal Antibody, 1ug/ul
Rabbit Anti-YAP1(Tyr407) Polyclonal Antibody, 1ug/ul
YAP1 (also known as Yes associated protein 1) was originally identified as a transcription factor that binds to the SH3 domain of the YES kinase (a Src protein kinase). More recently it has been identified as a candidate oncogene that promotes tumorigenesis in many different types of cancer.

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Yu-Gi-Oh! - Japanese import - Red-Eyes B. Dragon (YAP1-JP002) - Anniversary Pack - Limited Edition - Ultra Rare
Yu-Gi-Oh! - Japanese import - Red-Eyes B. Dragon (YAP1-JP002) - Anniversary Pack - Limited Edition - Ultra Rare
Yu-Gi-Oh! - Japanese import - Red-Eyes B. Dragon (YAP1-JP002) - Anniversary Pack - Limited Edition - Ultra Rare

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